Update: The A38 has now reopened.
The A38 northbound carriageway is currently closed near Chudleigh following a serious collision. Diversions are in place.
Emergency services were called at 3.45am after a Ford Transit van left the road and collided with a tree near to the Chudleigh turn off.
Three men have been taken to hospital and one of the men has sustained serious injuries.
The van was transporting six dogs who are all safe and have temporarily been taken to a local kennel
Accident investigator remain at the scene.